A daily dose of up to 600 milligrams of ALA is well tolerated by the human body. No adverse effects were observed on administration of 1,200 mg/day (600mg, 2 times/day) for 2 years and 1,800 mg/day (600 mg, 3 times/day) for 3 weeks in diabetic neuropathy patients under medical supervision. However, because of lack of long-term safety studies, ALA s…